The role of gut serotonin in visceral pain

We study how modulating gut epithelial serotonin availability impacts visceral pain and gut motility, which will help to determine potential new epithelial-restricted targets for IBS treatment.

The role of gestational SSRI exposure in the development of GI disorders.

We study how SSRI antidepressant exposure impacts GI function and pathology consistent with disorders of gut-brain interaction.

Linkage of trafficking chaperone p11 to serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brain

We study how p11 impacts 5-HT4 signaling in the gut and its associated functions in gut motility and enteric nervous system development.

The role of gut serotonin in anxiety and depression

We study how different sources of gut serotonin affect anxiety and depression associated behaviors.