The Margolis Lab at NYU

Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.

Sarah A Najjar, Lin Y. Hung, K. Margolis

Comprehensive Physiology, 2023

hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease.

Yujie Fan, James O. S. Hackland, A. Baggiolini, Lin Y. Hung, Huiyong Zhao, P. Zumbo, P. Oberst, Andrew P. Minotti, Emiliano Hergenreder, Sarah A Najjar, Zixing Huang, N. Cruz, Aaron Zhong, Mega Sidharta, Ting Zhou, E. de Stanchina, D. Betel, R. White, Michael Gershon, K. Margolis, L. Studer

Cell Stem Cell, 2023

Decreased Gut Microbiome Tryptophan Metabolism and Serotonergic Signaling in Patients With Persistent Mental Health and Gastrointestinal Symptoms After COVID-19

2022

John W. Blackett, Yiwei Sun, L. Purpura, K. Margolis, M. Elkind, Sheila O'Byrne, M. Wainberg, J. Abrams, Harris H. Wang, Lin Chang, D. Freedberg

Clinical and Translational Gastroenterology, 2022

How the Gut Feeds the Brain: A Newly Uncovered Gut-Brain Circuit for Appetite Suppression.

K. Margolis

Gastroenterology, 2022

Material Engineering in Gut Microbiome and Human Health

Letao Yang, Lin Y. Hung, Yuefei Zhu, Suwan Ding, K. Margolis, Kam W. Leong

Research, 2022

Materials Engineering in Gut Microbiome and Human Health Short title: Biomaterials Innovations Applied to Gut Microbiome Authors

Letao Yang, Lin Y. Hung, Yuefei Zhu, Suwan Ding, K. Margolis, Kam W. Leong

2022

Semantic Scholar

Presentation of the AGA Distinguished Achievement Award in Basic Science to Michael David Gershon, MD, AGAF.

M. Gershon, K. Margolis, G. Mawe

Gastroenterology, 2022

Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury.

M. Middelhoff, G. Valenti, L. Tomassoni, Y. Ochiai, B. Belin, R. Takahashi, E. Malagola, H. Nienhüser, Michael O. Finlayson, Y. Hayakawa, L. Zamechek, B. Renz, C. Westphalen, M. Quante, K. Margolis, P. Sims, P. Laise, A. Califano, M. Rao, M. Gershon, T. Wang

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2022

Liver involvement in children with SARS‐COV‐2 infection: Two distinct clinical phenotypes caused by the same virus

2021

Adriana Pere, A. Cantor, Bryan Rudolph, Jonathan Miller, D. Kogan-Liberman, Qi Gao, Bernardo Da Silva, Kara Gross Margolis, N. Ovchinsky, Mercedes Martinez

Liver international (Print), 2021

Gastrointestinal Symptoms Prevalent in Both Children with MIS-C and those with COVID-19

Jonathan Miller, Mercedes Martínez, K. Margolis

Gastroenterology, 2021

Semantic Scholar DOI PubMedCentral

Jonathan Miller, Mercedes Martínez, K. Margolis

Gastroenterology, 2021

The Microbiota-Gut-Brain Axis: From Motility to Mood.

K. Margolis, J. Cryan, E. Mayer

Gastroenterology, 2021

The gut, its microbiome, and the brain: connections and communications.

M. Gershon, K. Margolis

Journal of Clinical Investigation, 2021

Gastrointestinal Issues and Autism Spectrum Disorder.

M. Madra, Roey Ringel, K. Margolis

Psychiatric Clinics of North America, 2021

Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects

N. Jimenez-Vargas, Yang Yu, D. Jensen, D. Bok, Matthew Wisdom, R. Latorre, C. Lopez, J. Jaramillo-Polanco, C. Degro, M. Guzmán-Rodríguez, Q. Tsang, Zachary Snow, B. Schmidt, D. Reed, A. Lomax, K. Margolis, C. Stein, N. Bunnett, S. Vanner

Gut, 2021

The tactile sensors of the gut

Sarah A. Najjar, K. Margolis

Trends in Neurosciences, 2021

Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson’s disease

Y. Bhattarai, Jie Si, Meng Pu, O. Ross, P. McLean, L. Till, William Moor, M. Grover, K. Kandimalla, K. Margolis, G. Farrugia, P. Kashyap

Gut microbes, 2021

The α isoform of cGMP‐dependent protein kinase 1 (PKG1α) is expressed and functionally important in intrinsic primary afferent neurons of the guinea pig enteric nervous system

Z. S. Li, Lin Y. Hung, K. Margolis, R. Ambron, Y. Sung, M. Gershon

Neurogastroenterology and Motility, 2021

Acute Hepatitis Is a Prominent Presentation of the Multisystem Inflammatory Syndrome in Children: A Single‐Center Report

2020

A. Cantor, Jonathan Miller, P. Zachariah, Bernardo DaSilva, K. Margolis, Mercedes Martinez

Hepatology, 2020

Novel Aspects of Enteric Serotonergic Signaling in Health and Brain-Gut Disease.

Andrew Del Colle, Narek Israelyan, Kara Gross Margolis

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2020

Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019 in a Children's Hospital in New York City: Patient Characteristics and an Institutional Protocol for Evaluation, Management, and Follow-Up.

B. Jonat, M. Gorelik, A. Boneparth, Andrew S. Geneslaw, P. Zachariah, Amee M. Shah, Larisa Broglie, Juan Duran, K. Morel, M. Zorrilla, Leanne Svoboda, C. Johnson, Jennifer Cheng, M. Garzon, Wendy G. Silver, Kara Gross Margolis, C. Neunert, I. Lytrivi, J. Milner, S. Kernie, E. Cheung

Pediatric Critical Care Medicine, 2020

Gastrointestinal Symptoms as a Major Presentation Component of a Novel Multisystem Inflammatory Syndrome in Children That Is Related to Coronavirus Disease 2019: A Single Center Experience of 44 Cases

Jonathan Miller, A. Cantor, P. Zachariah, D. Ahn, Mercedes Martinez, K. Margolis

Gastroenterology, 2020

Leila H Shayegan, M. Garzon, K. Morel, Rachel E. Borlack, P. Vuguin, K. Margolis, Y. Demirdag, E. Pereira, C. Lauren

Pediatric dermatology, 2020

Autism Spectrum Disorder as a Brain-Gut-Microbiome Axis Disorder

Virginia Saurman, K. Margolis, R. A. Luna

Digestive Diseases and Sciences, 2020

Gut‐derived serotonin contributes to bone deficits in colitis

2019

B. Lavoie, J. Roberts, M. Haag, S. Spohn, K. Margolis, K. Sharkey, J. Lian, G. Mawe

Pharmacological Research, 2019

Lack of Associations Between Dietary Intake and Gastrointestinal Symptoms in Autism Spectrum Disorder

Bradley J. Ferguson, Kristen Dovgan, D. Severns, Shannon Martin, Sarah Marler, Kara Gross Margolis, M. Bauman, J. Veenstra-VanderWeele, K. Sohl, D. Beversdorf

Frontiers in Psychiatry, 2019

Prenatal stress and maternal immune dysregulation in autism spectrum disorders- potential points for intervention.

D. Beversdorf, H. Stevens, K. Margolis, J. A. Van de Water

Current pharmaceutical design, 2019

Building community in the gut: a role for mucosal serotonin

J. Hoffman, K. Margolis

Nature reviews: Gastroenterology & hepatology, 2019

Autism Speaks-Autism Treatment Network Gastrointestinal Signs and Symptoms Inventory-17

K. Margolis, T. Buie, J. B. Turner, Anna E. Silberman, J. Feldman, Katherine F. Murray, M. McSwiggan-Hardin, J. Levy, M. Bauman, J. Veenstra-VanderWeele, A. Whitaker, H. Winter

PsycTESTS Dataset, 2019

Effects of Serotonin and Slow-release 5-HTP on Gastrointestinal Motility in a Mouse Model of Depression.

Narek Israelyan, Andrew Del Colle, Zhishan Li, Yeji Park, Albert Xing, J. Jacobsen, R. A. Luna, D. Jensen, M. Madra, Virginia Saurman, Rayhana Rahim, R. Latorre, Kimberly Law, W. Carson, N. Bunnett, M. Caron, K. Margolis

Gastroenterology, 2019

Brain-Gut Axis: Clinical Implications.

2018

J. Khlevner, Yeji Park, K. Margolis

Gastroenterology Clinics of North America, 2018

Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder

K. Margolis, T. Buie, J. B. Turner, Anna E. Silberman, J. Feldman, Katherine F. Murray, M. McSwiggan-Hardin, J. Levy, M. Bauman, J. Veenstra-VanderWeele, A. Whitaker, H. Winter

Journal of Autism and Developmental Disorders, 2018

p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

M. Robson, M. Quinlan, K. Margolis, Paula A. Gajewski-Kurdziel, J. Veenstra-VanderWeele, M. Gershon, D. Watterson, R. Blakely

Proceedings of the National Academy of Sciences of the United States of America, 2018

Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.

Narek Israelyan, K. Margolis

Pharmacological Research, 2018

Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder

2017

Bradley J. Ferguson, Sarah Marler, Lily L. Altstein, E. Lee, Jill Akers, K. Sohl, Aaron McLaughlin, K. Hartnett, Briana M. Kille, M. Mazurek, E. Macklin, E. McDonnell, M. Barstow, M. Bauman, K. Margolis, J. Veenstra-VanderWeele, D. Beversdorf

Autism Research, 2017

Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis.

Kara Gross Margolis, J. Vittorio, M. Talavera, Karen Gluck, Zhishan Li, A. Iuga, Korey D. Stevanovic, Virginia Saurman, Narek Israelyan, M. Welch, M. Gershon

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2017

A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure

K. Margolis

Journal of Chemical Neuroanatomy, 2017

90 – Development of Gastrointestinal Motility

K. Margolis, J. Picoraro

2017

Hormones, Neurotransmitters, Growth Factors, Receptors, and Signaling Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis

K. Margolis, J. Vittorio, M. Talavera, Karen Gluck, Zhishan Li, A. Iuga, Korey D. Stevanovic, Virginia Saurman, Narek Israelyan, M. Welch, M. Gershon

2017

Semantic Scholar

Enteric Cholinergic Neurons Stimulate Muscarinic Receptors that Regulate Intestinal Mucosal Homeostasis and Inflammation

K. Margolis, Zhishan Li, Korey D. Stevanovic, Virginia Saurman, N. Kadakia, Albert Xing, M. Gershon

2017

Stromal Dclk1 Expression Labels Multi-Potential Neural Progenitor Cells in the Enteric Nervous System

M. Middelhoff, Y. Hayakawa, G. Valenti, Kosuke Sakitani, R. Takahashi, Takayuki Tanaka, Woosook Kim, Sama I. Sayin, Zinaida A. Dubeykovskaya, Zhengyu Jiang, Xiaowei Chen, Haibo Liu, H. Deng, Yagnesh H Tailor, K. Nagar, Timothy H. Chu, Svetlana L. Sabel, M. Rao, C. Westphalen, M. Quante, K. Margolis, M. Gershon, T. Wang

2017

KLF-5 extends its fingers to desmosomes: the next frontier for enteric epithelial research?

Narek Israelyan, K. Margolis

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2017

Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder

Sarah Marler, Bradley J. Ferguson, E. Lee, B. Peters, K. Williams, E. McDonnell, E. Macklin, P. Levitt, K. Margolis, D. Beversdorf, J. Veenstra-VanderWeele

Journal of Autism and Developmental Disorders, 2017

Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder

2016

Bradley J. Ferguson, Sarah Marler, Lily L. Altstein, E. Lee, M. Mazurek, Aaron McLaughlin, E. Macklin, E. McDonnell, D. Davis, A. Belenchia, C. H. Gillespie, C. Peterson, M. Bauman, K. Margolis, J. Veenstra-VanderWeele, D. Beversdorf

Brain, behavior, and immunity, 2016

Phenotypic Heterogeneity of Neutropenia and Gastrointestinal Illness Associated with G6PC3 Founder Mutation

Chana L. Glasser, J. Picoraro, Preti Jain, Sivan Kinberg, E. Rustia, Kara Gross Margolis, K. Anyane-Yeboa, A. Iglesias, N. Green

Journal of pediatric hematology/oncology, 2016

Associations between nutrient intake and gastrointestinal symptoms in autism spectrum disorder

D. Severns, Bradley J. Ferguson, Sarah Marler, Lily L. Altstein, E. Lee, M. Mazurek, Aaron McLaughlin, K. Hartnett, E. Macklin, E. McDonnell, D. Davis, A. Belenchia, C. H. Gillespie, C. Peterson, M. Bauman, K. Margolis, J. Veenstra-VanderWeele, D. Beversdorf

2016

Semantic Scholar

Enteric Neuronal Regulation of Intestinal Inflammation

K. Margolis, M. Gershon

Trends in Neurosciences, 2016

Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract.

K. Margolis, M. Gershon, M. Bogunovic

Trends in immunology, 2016

Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function.

K. Margolis, Zhishan Li, Korey D. Stevanovic, Virginia Saurman, Narek Israelyan, G. Anderson, Isaac Snyder, J. Veenstra-VanderWeele, R. Blakely, M. Gershon

Journal of Clinical Investigation, 2016

Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.

N. Terry, K. Margolis

Handbook of Experimental Pharmacology, 2016

Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder

Sarah Marler, Bradley J. Ferguson, E. Lee, B. Peters, K. Williams, E. McDonnell, E. Macklin, P. Levitt, C. H. Gillespie, G. Anderson, K. Margolis, D. Beversdorf, J. Veenstra-VanderWeele

Journal of Autism and Developmental Disorders, 2016

Association of Serotonin Transporter Promoter Polymorphism (5HTTLPR) with Microscopic Colitis and Ulcerative Colitis: Time to Be AsSERTive?

2015

Dana L. Goldner, K. Margolis

Digestive Diseases and Sciences, 2015

Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice.

2014

M. Welch, K. Margolis, Zhishan Li, M. Gershon

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2014

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

P. Muller, Balázs Koscsó, Gaurav Manohar Rajani, Korey D. Stevanovic, M. Berres, D. Hashimoto, A. Mortha, M. Leboeuf, Xiu-Min Li, D. Mucida, E. Stanley, S. Dahan, K. Margolis, M. Gershon, M. Merad, M. Bogunovic

Cell, 2014

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

2013

K. Margolis, Korey D. Stevanovic, Zhishan Li, Q. Yang, T. Oravecz, B. Zambrowicz, K. Jhaver, Alexander Diacou, M. Gershon

Gut, 2013

Neuronal serotonin regulates growth of the intestinal mucosa in mice.

2012

E. Gross, M. Gershon, K. Margolis, Z. Gertsberg, Zhishan Li, R. Cowles

Gastroenterology, 2012

Reduced Serotonin Reuptake Transporter (SERT) Function Causes Insulin Resistance and Hepatic Steatosis Independent of Food Intake

Xiaoning Chen, Kara J. Margolis, M. Gershon, G. Schwartz, J. Sze

PLoS ONE, 2012

Expression level of Hand2 affects specification of enteric neurons and gastrointestinal function in mice.

2011

F. D'Autréaux, K. Margolis, J. Roberts, Korey D. Stevanovic, G. Mawe, Zhishan Li, N. Karamooz, A. Ahuja, Y. Morikawa, P. Cserjesi, Wanda Setlick, M. Gershon

Gastroenterology, 2011

Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways.

I. Karagiannides, Kyriaki Bakirtzi, E. Kokkotou, D. Stavrakis, K. Margolis, Thomas Thomou, N. Giorgadze, J. Kirkland, C. Pothoulakis

Endocrinology, 2011

Enteric neuronal density contributes to the severity of intestinal inflammation.

K. Margolis, Korey D. Stevanovic, N. Karamooz, Z. Li, A. Ahuja, F. D'Autréaux, Virginia Saurman, A. Chalazonitis, M. Gershon

Gastroenterology, 2011