Our research is focused on discovering the ways in which we can alter gut signaling to treat disorders of the brain and the GI tract.  We have uncovered, and are continuing to reveal, key insights into how gut signaling, involving gut serotonin, nutrition, and/or the microbiome, play roles in mood disorders (depression and anxiety), disorders of gut-brain interaction (DGBI; e.g., irritable bowel syndrome) and/or neurodevelopmental disorders, including autism spectrum disorders. We are also developing novel drugs and drug delivery systems to treat brain-gut axis conditions.